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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets.
Postema, Merel C; van Rooij, Daan; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume; Behrmann, Marlene; Filho, Geraldo Busatto; Calderoni, Sara; Calvo, Rosa; Daly, Eileen; Deruelle, Christine; Di Martino, Adriana; Dinstein, Ilan; Duran, Fabio Luis S; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Fair, Damien; Fedor, Jennifer; Feng, Xin; Fitzgerald, Jackie; Floris, Dorothea L; Freitag, Christine M; Gallagher, Louise; Glahn, David C; Gori, Ilaria; Haar, Shlomi; Hoekstra, Liesbeth; Jahanshad, Neda; Jalbrzikowski, Maria; Janssen, Joost; King, Joseph A; Kong, Xiang Zhen; Lazaro, Luisa; Lerch, Jason P; Luna, Beatriz; Martinho, Mauricio M; McGrath, Jane; Medland, Sarah E; Muratori, Filippo; Murphy, Clodagh M; Murphy, Declan G M; O'Hearn, Kirsten; Oranje, Bob; Parellada, Mara; Puig, Olga; Retico, Alessandra; Rosa, Pedro; Rubia, Katya; Shook, Devon.
Afiliação
  • Postema MC; Department of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • van Rooij D; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Anagnostou E; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Department of Pediatrics, University of Toronto, Toronto, USA.
  • Arango C; Child and Adolescent Psychiatry Department, Gregorio Marañón General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
  • Auzias G; Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS, Marseille, France.
  • Behrmann M; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Filho GB; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
  • Calderoni S; IRCCS Stella Maris Foundation, viale del Tirreno 331, 56128, Pisa, Italy.
  • Calvo R; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Daly E; Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
  • Deruelle C; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.
  • Di Martino A; Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS, Marseille, France.
  • Dinstein I; Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY, USA.
  • Duran FLS; Department of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
  • Durston S; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
  • Ecker C; Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Ehrlich S; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
  • Fair D; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
  • Fedor J; Department of Child and Adolescent Psychiatry, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
  • Feng X; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
  • Fitzgerald J; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Floris DL; BioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin, 130012, China.
  • Freitag CM; Department of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
  • Gallagher L; The Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
  • Glahn DC; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Gori I; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
  • Haar S; Department of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
  • Hoekstra L; The Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
  • Jahanshad N; Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115-5724, USA.
  • Jalbrzikowski M; Olin Neuropsychiatric Research Center, Hartford, CT, USA.
  • Janssen J; National Institute for Nuclear Physics, Pisa Division, Largo B. Pontecorvo 3, 56124, Pisa, Italy.
  • King JA; Department of Bioengineering, Imperial College London, London, UK.
  • Kong XZ; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Lazaro L; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands.
  • Lerch JP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
  • Luna B; Department of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
  • Martinho MM; Child and Adolescent Psychiatry Department, Gregorio Marañón General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
  • McGrath J; Department of Child and Adolescent Psychiatry, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
  • Medland SE; Department of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Muratori F; Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
  • Murphy CM; Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Murphy DGM; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • O'Hearn K; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Oranje B; Department of Neuropsychiatry, Universidade Federal de Santa Maria, Santa Maria, Brazil.
  • Parellada M; Department of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
  • Puig O; The Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
  • Retico A; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Rosa P; IRCCS Stella Maris Foundation, viale del Tirreno 331, 56128, Pisa, Italy.
  • Rubia K; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Shook D; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.
Nat Commun ; 10(1): 4958, 2019 10 31.
Article em En | MEDLINE | ID: mdl-31673008
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2019 Tipo de documento: Article