C99 selectively accumulates in vulnerable neurons in Alzheimer's disease.
Alzheimers Dement
; 16(2): 273-282, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31677937
ABSTRACT
INTRODUCTION:
The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer's disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid b (Ab) contribute to the onset of AD.METHODS:
We developed a sensitive assay adapted to the detection of C99, the direct precursor of b-amyloid. Three postmortem groups were studied control with normal and stable cognition; patients with moderate AD, and individuals with severe AD. The amount of C99 and Aß was quantified and correlated with the severity of AD.RESULTS:
C99 accumulates in vulnerable neurons, and its levels correlate with the degree of cognitive impairment in patients suffering from AD. In contrast, Aß levels are increased in both vulnerable and resistant brain areas.DISCUSSION:
These results raise the possibility that C99, rather than Aß plaques, is responsible for the death of nerve cells in AD.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Precursor de Proteína beta-Amiloide
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Progressão da Doença
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Doença de Alzheimer
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Neurônios
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article