Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.

Garic, Dusan; De Sanctis, Juan B; Dumut, Daciana Catalina; Shah, Juhi; Peña, Maria Johanna; Youssef, Mina; Petrof, Basil J; Kopriva, Francisek; Hanrahan, John W; Hajduch, Marian; Radzioch, Danuta

Garic, Dusan; De Sanctis, Juan B; Dumut, Daciana Catalina; Shah, Juhi; Peña, Maria Johanna; Youssef, Mina; Petrof, Basil J; Kopriva, Francisek; Hanrahan, John W; Hajduch, Marian; Radzioch, Danuta.

Afiliação

Garic D; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada.
De Sanctis JB; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Institute of Immunology, Faculty of Medicine, Universidad Central de Venezuela, Bolivarian Republic of Venezuela.
Dumut DC; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada.
Shah J; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada.
Peña MJ; Institute of Immunology, Faculty of Medicine, Universidad Central de Venezuela, Bolivarian Republic of Venezuela.
Youssef M; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada.
Petrof BJ; Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
Kopriva F; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Hanrahan JW; Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Hajduch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Radzioch D; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec

Biochim Biophys Acta Mol Cell Biol Lipids ; 1865(2): 158538, 2020 02.

Article em En | MEDLINE | ID: mdl-31678518

Assuntos

Fibrose Cística/complicações; Fenretinida/administração & dosagem; Pulmão/efeitos dos fármacos; Pneumonia/prevenção & controle; Infecções por Pseudomonas/prevenção & controle; Administração Oral; Animais; Ácido Araquidônico/metabolismo; Linhagem Celular; Fibrose Cística/genética; Fibrose Cística/patologia; Modelos Animais de Doenças; Ácidos Docosa-Hexaenoicos/metabolismo; Humanos; Pulmão/metabolismo; Pulmão/patologia; Camundongos; Camundongos Endogâmicos CFTR; Mucina-5AC/metabolismo; Mucina-5B/metabolismo; Muco/metabolismo; Fosfolipídeos/metabolismo; Pneumonia/microbiologia; Pneumonia/patologia; Infecções por Pseudomonas/microbiologia; Infecções por Pseudomonas/patologia; Pseudomonas aeruginosa/patogenicidade; Ratos; Mucosa Respiratória/citologia; Mucosa Respiratória/metabolismo

Palavras-chave

CFTR; Cystic fibrosis; Mucins; PUFAs

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Infecções por Pseudomonas / Fenretinida / Fibrose Cística / Pulmão Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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