Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity.

Nunhart, Patrik; Konkolová, Eva; Janovec, Ladislav; Jendzelovský, Rastislav; Vargová, Jana; Sevc, Juraj; Matejová, Mária; Miltáková, Beata; Fedorocko, Peter; Kozurkova, Mária

Nunhart, Patrik; Konkolová, Eva; Janovec, Ladislav; Jendzelovský, Rastislav; Vargová, Jana; Sevc, Juraj; Matejová, Mária; Miltáková, Beata; Fedorocko, Peter; Kozurkova, Mária.

Afiliação

Nunhart P; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Konkolová E; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Janovec L; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Jendzelovský R; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Vargová J; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Sevc J; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Matejová M; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Miltáková B; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Fedorocko P; Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic.
Kozurkova M; Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Safárik University in Kosice, Srobárova 2, 041 54 Kosice, Slovak Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Electronic address: maria.kozu

Bioorg Chem ; 94: 103393, 2020 01.

Article em En | MEDLINE | ID: mdl-31679839

Assuntos

Acridinas/farmacologia; Antineoplásicos/farmacologia; DNA/efeitos dos fármacos; Inibidores da Topoisomerase I/farmacologia; Inibidores da Topoisomerase II/farmacologia; Células A549; Acridinas/síntese química; Acridinas/química; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Bovinos; Proliferação de Células/efeitos dos fármacos; DNA Topoisomerases Tipo I/metabolismo; DNA Topoisomerases Tipo II/metabolismo; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Halogenação; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Inibidores da Topoisomerase I/síntese química; Inibidores da Topoisomerase I/química; Inibidores da Topoisomerase II/síntese química; Inibidores da Topoisomerase II/química

Palavras-chave

3,6,9-Trisubstituted acridine derivatives; Cytotoxicity; Fluorine; Lung carcinoma cells; Spectroscopic techniques; calf thymus DNA; topoisomerases I/II

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acridinas / DNA / Inibidores da Topoisomerase I / Inibidores da Topoisomerase II / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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