EPD in 2020: enhanced data visualization and extension to ncRNA promoters.
Nucleic Acids Res
; 48(D1): D65-D69, 2020 01 08.
Article
em En
| MEDLINE
| ID: mdl-31680159
ABSTRACT
The Eukaryotic Promoter Database (EPD), available online at https//epd.epfl.ch, provides accurate transcription start site (TSS) information for promoters of 15 model organisms plus corresponding functional genomics data that can be viewed in a genome browser, queried or analyzed via web interfaces, or exported in standard formats (FASTA, BED, CSV) for subsequent analysis with other tools. Recent work has focused on the improvement of the EPD promoter viewers, which use the UCSC Genome Browser as visualization platform. Thousands of high-resolution tracks for CAGE, ChIP-seq and similar data have been generated and organized into public track hubs. Customized, reproducible promoter views, combining EPD-supplied tracks with native UCSC Genome Browser tracks, can be accessed from the organism summary pages or from individual promoter entries. Moreover, thanks to recent improvements and stabilization of ncRNA gene catalogs, we were able to release promoter collections for certain classes of ncRNAs from human and mouse. Furthermore, we developed automatic computational protocols to assign orphan TSS peaks to downstream genes based on paired-end (RAMPAGE) TSS mapping data, which enabled us to add nearly 9000 new entries to the human promoter collection. Since our last article in this journal, EPD was extended to five more model organisms rhesus monkey, rat, dog, chicken and Plasmodium falciparum.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Regiões Promotoras Genéticas
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Biologia Computacional
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RNA não Traduzido
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Genômica
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Bases de Dados de Ácidos Nucleicos
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Células Eucarióticas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article