6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.

Saepua, Siriporn; Sadorn, Karoon; Vanichtanankul, Jarunee; Anukunwithaya, Tosapol; Rattanajak, Roonglawan; Vitsupakorn, Danoo; Kamchonwongpaisan, Sumalee; Yuthavong, Yongyuth; Thongpanchang, Chawanee

Saepua, Siriporn; Sadorn, Karoon; Vanichtanankul, Jarunee; Anukunwithaya, Tosapol; Rattanajak, Roonglawan; Vitsupakorn, Danoo; Kamchonwongpaisan, Sumalee; Yuthavong, Yongyuth; Thongpanchang, Chawanee.

Afiliação

Saepua S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Sadorn K; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Vanichtanankul J; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Anukunwithaya T; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Rattanajak R; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Vitsupakorn D; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Yuthavong Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Thongpanchang C; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand. Electronic address: chawanee@biotec.or.th.

Bioorg Med Chem ; 27(24): 115158, 2019 12 15.

Article em En | MEDLINE | ID: mdl-31685330

Assuntos

Antimaláricos/farmacologia; Plasmodium falciparum/efeitos dos fármacos; Pirimetamina/análogos & derivados; Animais; Antimaláricos/química; Chlorocebus aethiops; Desenho de Fármacos; Resistência a Medicamentos; Antagonistas do Ácido Fólico/química; Antagonistas do Ácido Fólico/farmacologia; Modelos Moleculares; Estrutura Molecular; Conformação Proteica; Pirimetamina/química; Pirimetamina/farmacologia; Tetra-Hidrofolato Desidrogenase/química; Tetra-Hidrofolato Desidrogenase/metabolismo; Células Vero

Palavras-chave

Dihydrofolate reductase inhibitors; Dihydropyrimidines; Malaria; Plasmodium falciparum

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Pirimetamina / Antimaláricos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google