Translational pathology, genomics and the development of systemic therapies for acral melanoma.
Semin Cancer Biol
; 61: 149-157, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31689494
ABSTRACT
Acral melanomas arise on the non-hair bearing skin of the palms, soles and in the nail beds. These rare tumors comprise 2-3 % of all melanomas, are not linked to UV-exposure, and represent the most frequent subtype of melanomas in patients of Asian, African and Hispanic origin. Although recent work has revealed candidate molecular events that underlie acral melanoma development, this knowledge is not yet been translated into efficacious local, regional, or systemic therapies. In the current review, we describe the clinical characteristics of acral melanoma and outline the genetic basis of acral melanoma development. Further discussion is given to the current status of systemic therapy for acral melanoma with a focus on ongoing developments in both immunotherapy and targeted therapy for the treatment of advanced disease.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Predisposição Genética para Doença
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Genômica
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Melanoma
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article