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Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Yeong, Keng Yoon; Khaw, Kooi Yeong; Takahashi, Yukari; Itoh, Yukihiro; Murugaiyah, Vikneswaran; Suzuki, Takayoshi.
Afiliação
  • Yeong KY; School of Science, Monash University Malaysia Campus, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia. Electronic address: yeong.kengyoon@monash.edu.
  • Khaw KY; School of Pharmacy, Monash University Malaysia Campus, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia; Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
  • Takahashi Y; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
  • Itoh Y; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
  • Murugaiyah V; Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
  • Suzuki T; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan; The Institute of Scientific and Industrial Research, Osaka University, Japan; CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0
Bioorg Chem ; 94: 103403, 2020 01.
Article em En | MEDLINE | ID: mdl-31711765
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Garcinia mangostana / Xantonas / Inibidores Enzimáticos / Descoberta de Drogas / Sirtuína 2 / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Garcinia mangostana / Xantonas / Inibidores Enzimáticos / Descoberta de Drogas / Sirtuína 2 / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article