Neuroprotective Dihydro-ß-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii.
J Nat Prod
; 82(11): 3096-3103, 2019 11 22.
Article
em En
| MEDLINE
| ID: mdl-31713425
ABSTRACT
Twenty-one dihydro-ß-agarofuran derivatives were purified from the seeds of Euonymus maackii, and eight compounds (1-8) were identified as new natural products. Their structures were deduced by extensive spectroscopic analysis, X-ray diffraction studies, and comparison of observed and reported NMR data. Compounds 10, 12, 17, and 18 significantly increased the cell viability of Aß25-35-treated SH-SY5Y cells with effects similar to that of epigallocatechin gallate (EGCG). In addition, the abundant compound 9 reduced the seizure-like locomotor activity of zebrafish at 10 µM compared with a pentylenetetrazol-treated group.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Sesquiterpenos
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Fármacos Neuroprotetores
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Euonymus
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article