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Nanostructured lipid carriers for oral delivery of silymarin: Improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model.
Piazzini, Vieri; Micheli, Laura; Luceri, Cristina; D'Ambrosio, Mario; Cinci, Lorenzo; Ghelardini, Carla; Bilia, Anna Rita; Di Cesare Mannelli, Lorenzo; Bergonzi, Maria Camilla.
Afiliação
  • Piazzini V; Department of Chemistry, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
  • Micheli L; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Luceri C; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • D'Ambrosio M; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Cinci L; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Ghelardini C; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Bilia AR; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Di Cesare Mannelli L; NEUROFARBA, Department of Neurosciences, Psychology, Drug Research and Children's Health, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
  • Bergonzi MC; Department of Chemistry, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: mc.bergonzi@unifi.it.
Int J Pharm ; 572: 118838, 2019 Dec 15.
Article em En | MEDLINE | ID: mdl-31715362
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silimarina / Sistemas de Liberação de Medicamentos / Síndrome Metabólica / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silimarina / Sistemas de Liberação de Medicamentos / Síndrome Metabólica / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2019 Tipo de documento: Article