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Obesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign.
Nordstrand, Sebjørg E H; Juvodden, Hilde T; Viste, Rannveig; Rootwelt, Terje; Karlsen, Tor-Ivar; Thorsby, Per M; Swanson, David; Nilsen, Kristian Bernhard; Hansen, Berit H; Knudsen-Heier, Stine.
Afiliação
  • Nordstrand SEH; Department of Rare Disorders, Division of Paediatric and Adolescent Medicine, Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias (NevSom), Oslo University Hospital, Norway.
  • Juvodden HT; Faculty of Medicine, University of Oslo, Norway.
  • Viste R; Department of Rare Disorders, Division of Paediatric and Adolescent Medicine, Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias (NevSom), Oslo University Hospital, Norway.
  • Rootwelt T; Faculty of Medicine, University of Oslo, Norway.
  • Karlsen TI; Department of Rare Disorders, Division of Paediatric and Adolescent Medicine, Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias (NevSom), Oslo University Hospital, Norway.
  • Thorsby PM; Faculty of Medicine, University of Oslo, Norway.
  • Swanson D; Faculty of Medicine, University of Oslo, Norway.
  • Nilsen KB; Department of Paediatrics, Oslo University Hospital, Norway.
  • Hansen BH; Faculty of Health and Sports Sciences, University of Agder, Norway.
  • Knudsen-Heier S; Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Aker, Norway.
Sleep ; 43(5)2020 05 12.
Article em En | MEDLINE | ID: mdl-31724727
STUDY OBJECTIVES: Narcolepsy type 1 (NT1) may be complicated by comorbidities. We aimed to study the extent of obesity and other medical comorbidities in a Norwegian population of NT1 patients with debut of symptoms after the 2009 H1N1 influenza epidemic and vaccination campaign. We also aimed to explore factors associated with obesity. METHODS: Ninety-one patients (48 children and 43 adults) were included in this cross-sectional study, 80 of whom were H1N1-vaccinated. All participants were hospitalized and underwent sleep investigation and physical examination, and completed a semi-structured clinical interview. RESULTS: In children, 16 females (70%) and 10 males (40%) were classified as overweight or obese. Twenty children (42%) had a co-existing medical disorder. Medical comorbidity was significantly positively associated with BMI in children (p = .032). In adults, 19 females (58%) and 7 males (70%) were classified as overweight or obese. Twenty-six adults (61%) had a co-existing medical disorder. We found no factors significantly associated with BMI in adults. On a fatigue scale from 0 to 100, lower scores indicating more fatigue, we found a mean (SD) total fatigue score of 50 (17) in children and 39 (16) in adults. CONCLUSION: In a cohort of predominantly H1N1-vaccinated NT1 patients, we found a high prevalence of overweight or obesity. Half of the cohort presented with one or more additional medical comorbidities, and patients reported a clinically relevant degree of fatigue. Our findings highlight the importance of carefully monitoring patients with NT1 with regard to the development of obesity, which is a significant risk factor for cardiovascular disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H1N1 / Epidemias / Narcolepsia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H1N1 / Epidemias / Narcolepsia Idioma: En Ano de publicação: 2020 Tipo de documento: Article