The ion selectivity filter is not an activation gate in TRPV1-3 channels.

Jara-Oseguera, Andrés; Huffer, Katherine E; Swartz, Kenton J

Jara-Oseguera, Andrés; Huffer, Katherine E; Swartz, Kenton J.

Afiliação

Jara-Oseguera A; Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Huffer KE; Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Swartz KJ; Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.

Elife ; 82019 11 14.

Article em En | MEDLINE | ID: mdl-31724952

Assuntos

Ativação do Canal Iônico; Canais de Cátion TRPV/metabolismo; Animais; Cátions/farmacologia; Células HEK293; Humanos; Ativação do Canal Iônico/efeitos dos fármacos; Íons; Camundongos; Ratos; Prata/farmacologia

Palavras-chave

TRP channel; TRPV2; TRPV3; activation gate; human; ion channel gating; molecular biophysics; mouse; rat; structural biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação do Canal Iônico / Canais de Cátion TRPV Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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