The impact of overweight on renal toxicity in patients treated with dexamethasone, high-dose cytarabine, and cisplatin.
Int J Hematol
; 111(3): 396-400, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31728828
ABSTRACT
The combination of dexamethasone, high-dose cytarabine, and cisplatin (DHAP) is used as salvage chemotherapy for relapsed or refractory lymphoma. It includes the administration of cisplatin in a single dose of 100 mg/m2, and renal toxicity is a common adverse event. In this study, we retrospectively analyzed the risk factors for renal toxicity (≥ grade 2) in 74 patients who received DHAP as salvage chemotherapy. Regarding maximal renal toxicities, 38 (51.4%), 6 (8.1%), and 1 (1.4%) patients had grade 2, 3, and 4 toxicities, respectively. Multivariate analyses revealed that overweight (body mass index ≥ 25) was an independent predictive factor for renal toxicity of ≥ grade 2 (odds ratio [OR] 4.08, P = 0.032). A subgroup analysis for patients with diffuse large B cell lymphoma treated with DHAP as second-line therapy (n = 44) confirmed that overweight was an independent risk factor (OR 5.28, P = 0.049). In conclusion, we demonstrated that overweight was an independent risk factor for renal toxicity of ≥ grade 2 in patients who received DHAP. Further clinical studies will be needed to identify a method to decrease renal toxicities after the administration of cisplatin.
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Base de dados:
MEDLINE
Assunto principal:
Dexametasona
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Cisplatino
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Citarabina
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Sobrepeso
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Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article