Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design.

Kamariah, Neelagandan; Ragunathan, Priya; Shin, Joon; Saw, Wuan-Geok; Wong, Chui-Fann; Dick, Thomas; Grüber, Gerhard

Kamariah, Neelagandan; Ragunathan, Priya; Shin, Joon; Saw, Wuan-Geok; Wong, Chui-Fann; Dick, Thomas; Grüber, Gerhard.

Afiliação

Kamariah N; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
Ragunathan P; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
Shin J; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
Saw WG; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
Wong CF; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
Dick T; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
Grüber G; Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore. Electronic address: ggrueber@ntu.edu.sg.

Prog Biophys Mol Biol ; 152: 64-73, 2020 05.

Article em En | MEDLINE | ID: mdl-31743686

Assuntos

Antituberculosos/metabolismo; Proteínas de Bactérias/metabolismo; Inibidores Enzimáticos/metabolismo; ATPases Mitocondriais Próton-Translocadoras/metabolismo; Mycobacterium tuberculosis/metabolismo; Tuberculose/tratamento farmacológico; Trifosfato de Adenosina/metabolismo; Sequência de Aminoácidos; Desenho de Fármacos; Humanos; Modelos Moleculares; Ligação Proteica; Conformação Proteica; Relação Estrutura-Atividade

Palavras-chave

Adaptation mechanisms; Bioenergetics; Drug discovery; F-ATP synthase; Mycobacterium; Tuberculosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tuberculose / ATPases Mitocondriais Próton-Translocadoras / Inibidores Enzimáticos / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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