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Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak, Irem; Maier, Carina R; Schmitz, Werner; Campbell, Andrew D; Dankworth, Beatrice; Ade, Carsten P; Walz, Susanne; Paauwe, Madelon; Kalogirou, Charis; Marouf, Hecham; Rosenfeldt, Mathias T; Gay, David M; McGregor, Grace H; Sansom, Owen J; Schulze, Almut.
Afiliação
  • Kaymak I; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Maier CR; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Schmitz W; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Campbell AD; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
  • Dankworth B; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Ade CP; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Walz S; Comprehensive Cancer Center Mainfranken, Core Unit Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.
  • Paauwe M; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
  • Kalogirou C; Department of Urology, University Hospital Würzburg, Würzburg, Germany.
  • Marouf H; Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Rosenfeldt MT; Department of Pathology, University Hospital Würzburg, Würzburg, Germany.
  • Gay DM; Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
  • McGregor GH; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
  • Sansom OJ; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Schulze A; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
Cancer Res ; 80(2): 189-203, 2020 01 15.
Article em En | MEDLINE | ID: mdl-31744820
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Ubiquinona / Proteína de Ligação a Elemento Regulador de Esterol 2 / Ácido Mevalônico / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Ubiquinona / Proteína de Ligação a Elemento Regulador de Esterol 2 / Ácido Mevalônico / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article