Lathyrane diterpenes from Euphorbia lathyris and the potential mechanism to reverse the multi-drug resistance in HepG2/ADR cells.

Yang, Tao; Wang, Siyi; Li, Hongmei; Zhao, Qun; Yan, Shili; Dong, Miao; Liu, Dan; Chen, Xuanqin; Li, Rongtao

Yang, Tao; Wang, Siyi; Li, Hongmei; Zhao, Qun; Yan, Shili; Dong, Miao; Liu, Dan; Chen, Xuanqin; Li, Rongtao.

Afiliação

Yang T; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Wang S; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Li H; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Zhao Q; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Yan S; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Dong M; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China.
Liu D; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China. Electronic address: liudan0626@163.com.
Chen X; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China. Electronic address: chenxuanqin12
Li R; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650093, China. Electronic address: lrt512@163.com.

Biomed Pharmacother ; 121: 109663, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31751870

Assuntos

Diterpenos/farmacologia; Resistência a Múltiplos Medicamentos/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Euphorbia/química; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Linhagem Celular Tumoral; Doxorrubicina/farmacologia; Células Hep G2; Humanos; Simulação de Acoplamento Molecular/métodos; Sementes/química

Palavras-chave

Euphorbia lathyrism; Lathyrane diterpenes; Multi-drug resistance; P-glycoprotein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos / Euphorbia / Diterpenos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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