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Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
Moya, Iván M; Castaldo, Stéphanie A; Van den Mooter, Laura; Soheily, Soheil; Sansores-Garcia, Leticia; Jacobs, Jelle; Mannaerts, Inge; Xie, Jun; Verboven, Elisabeth; Hillen, Hanne; Algueró-Nadal, Ana; Karaman, Ruchan; Van Haele, Matthias; Kowalczyk, Weronika; De Waegeneer, Maxime; Verhulst, Stefaan; Karras, Panagiotis; van Huffel, Leen; Zender, Lars; Marine, Jean-Christophe; Roskams, Tania; Johnson, Randy; Aerts, Stein; van Grunsven, Leo A; Halder, Georg.
Afiliação
  • Moya IM; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Castaldo SA; Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito, Ecuador.
  • Van den Mooter L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Soheily S; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Sansores-Garcia L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Jacobs J; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Mannaerts I; VIB Center for Brain and Disease Research and KU Leuven Center for Human Genetics, University of Leuven, Leuven, Belgium.
  • Xie J; Liver Cell Biology Research Group, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
  • Verboven E; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Hillen H; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Algueró-Nadal A; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Karaman R; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Van Haele M; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Kowalczyk W; Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
  • De Waegeneer M; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Verhulst S; VIB Center for Brain and Disease Research and KU Leuven Center for Human Genetics, University of Leuven, Leuven, Belgium.
  • Karras P; Liver Cell Biology Research Group, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
  • van Huffel L; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and Department of Oncology, KU Leuven, Leuven, Belgium.
  • Zender L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  • Marine JC; Department of Medical Oncology and Pneumology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
  • Roskams T; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Johnson R; iFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumour Therapies," University of Tuebingen, Tuebingen, Germany.
  • Aerts S; Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and Department of Oncology, KU Leuven, Leuven, Belgium.
  • van Grunsven LA; Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
  • Halder G; Department of Cancer Biology, Program in Cancer Biology, Graduate School for Biological Sciences GSBS, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Science ; 366(6468): 1029-1034, 2019 11 22.
Article em En | MEDLINE | ID: mdl-31754005
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Colangiocarcinoma / Proteínas de Ciclo Celular / Hepatócitos / Proteínas Adaptadoras de Transdução de Sinal / Neoplasias Hepáticas Experimentais Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transativadores / Colangiocarcinoma / Proteínas de Ciclo Celular / Hepatócitos / Proteínas Adaptadoras de Transdução de Sinal / Neoplasias Hepáticas Experimentais Idioma: En Ano de publicação: 2019 Tipo de documento: Article