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Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.
Garai, Sumanta; Kulkarni, Pushkar M; Schaffer, Peter C; Leo, Luciana M; Brandt, Asher L; Zagzoog, Ayat; Black, Tallan; Lin, Xiaoyan; Hurst, Dow P; Janero, David R; Abood, Mary E; Zimmowitch, Anaelle; Straiker, Alex; Pertwee, Roger G; Kelly, Melanie; Szczesniak, Anna-Maria; Denovan-Wright, Eileen M; Mackie, Ken; Hohmann, Andrea G; Reggio, Patricia H; Laprairie, Robert B; Thakur, Ganesh A.
Afiliação
  • Garai S; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
  • Kulkarni PM; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
  • Schaffer PC; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.
  • Leo LM; Center for Substance Abuse Research, Lewis Katz School of Medicine , Temple University , Philadelphia , Pennsylvania 19140 , United States.
  • Brandt AL; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
  • Zagzoog A; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
  • Black T; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
  • Lin X; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
  • Hurst DP; Center for Drug Discovery , University of North Carolina Greensboro , Greensboro , North Carolina 27402 , United States.
  • Janero DR; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences, Department of Chemistry and Chemical Biology, College of Science, and Health Sciences Entrepreneurs , Northeastern University , Boston , Massachusetts 02115 , United States.
  • Abood ME; Center for Substance Abuse Research, Lewis Katz School of Medicine , Temple University , Philadelphia , Pennsylvania 19140 , United States.
  • Zimmowitch A; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
  • Straiker A; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
  • Pertwee RG; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences , University of Aberdeen , Aberdeen AB25 2ZD , Scotland, U.K.
  • Kelly M; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
  • Szczesniak AM; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
  • Denovan-Wright EM; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
  • Mackie K; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
  • Hohmann AG; Program in Neuroscience, Psychological and Brain Sciences, and Gill Center for Biomolecular Science , Indiana University , Bloomington , Indiana 47405 , United States.
  • Reggio PH; Center for Drug Discovery , University of North Carolina Greensboro , Greensboro , North Carolina 27402 , United States.
  • Laprairie RB; College of Pharmacy and Nutrition , University of Saskatchewan , 104 Clinic Pl , Saskatoon , SK S7N2Z4 , Canada.
  • Thakur GA; Department of Pharmacology, Faculty of Medicine , Dalhousie University , 5850 College St , Halifax , NS , B3H4R2 , Canada.
J Med Chem ; 63(2): 542-568, 2020 01 23.
Article em En | MEDLINE | ID: mdl-31756109
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Receptor CB1 de Canabinoide / Flúor / Indóis / Nitrogênio Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Receptor CB1 de Canabinoide / Flúor / Indóis / Nitrogênio Idioma: En Ano de publicação: 2020 Tipo de documento: Article