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Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO).
Ikehara, Hajime; Fujii, Katsunori; Miyashita, Toshiyuki; Ikemoto, Yu; Nagamine, Marina; Shimojo, Naoki; Umezawa, Akihiro.
Afiliação
  • Ikehara H; Center for Regenerative Medicine, National Center for Child Health and Development Research Institute, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan.
  • Fujii K; Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Miyashita T; Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Ikemoto Y; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan.
  • Nagamine M; Center for Regenerative Medicine, National Center for Child Health and Development Research Institute, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan.
  • Shimojo N; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan.
  • Umezawa A; Center for Regenerative Medicine, National Center for Child Health and Development Research Institute, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan.
Lab Invest ; 100(4): 657-664, 2020 04.
Article em En | MEDLINE | ID: mdl-31758086
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Síndrome do Nevo Basocelular / Células-Tronco Neurais / Proteína GLI1 em Dedos de Zinco / Receptor Smoothened Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Síndrome do Nevo Basocelular / Células-Tronco Neurais / Proteína GLI1 em Dedos de Zinco / Receptor Smoothened Idioma: En Ano de publicação: 2020 Tipo de documento: Article