Efficient induction of cytotoxic T lymphocytes in hepatocellular carcinoma using the HLA-A2-restricted survivin peptide in vitro.
Exp Cell Res
; 386(2): 111741, 2020 01 15.
Article
em En
| MEDLINE
| ID: mdl-31759968
ABSTRACT
Survivin is a newly identified tumour-associated antigen and has been demonstrated to be an excellent target for immunotherapy in several cancers, but its role in hepatocellular carcinoma treatment is still unknown. In this study, survivin-derived peptide-specific cytotoxic T lymphocytes (CTLs) from peripheral blood mononuclear cells of healthy donors were induced by multiple stimulations with HLA-A2- restricted survivin peptide-pulsed T2 cells. The induced CTLs exhibited specific lysis of T2 cells pulsed with the peptide and HLA-A2+ hepatocellular carcinoma cells expressing survivin, while HLA-A2+ hepatocellular carcinoma cell lines that did not express survivin were not recognized by the CTLs. These results suggest that the survivin peptide epitope could be a potential target of specific immunotherapy for HLA-A2+ patients with hepatocellular carcinoma.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Linfócitos T Citotóxicos
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Antígeno HLA-A2
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Células Th2
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Citotoxicidade Imunológica
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Survivina
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article