Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia.

Jain, Manish; Dhanesha, Nirav; Doddapattar, Prakash; Chorawala, Mehul R; Nayak, Manasa K; Cornelissen, Anne; Guo, Liang; Finn, Aloke V; Lentz, Steven R; Chauhan, Anil K

Jain, Manish; Dhanesha, Nirav; Doddapattar, Prakash; Chorawala, Mehul R; Nayak, Manasa K; Cornelissen, Anne; Guo, Liang; Finn, Aloke V; Lentz, Steven R; Chauhan, Anil K.

Afiliação

Jain M; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Dhanesha N; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Doddapattar P; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Chorawala MR; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Nayak MK; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Cornelissen A; CVPath Institute Inc., Gaithersburg, Maryland, USA.
Guo L; CVPath Institute Inc., Gaithersburg, Maryland, USA.
Finn AV; CVPath Institute Inc., Gaithersburg, Maryland, USA.
Lentz SR; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.
Chauhan AK; Department of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, Iowa, USA.

J Clin Invest ; 130(1): 295-314, 2020 01 02.

Article em En | MEDLINE | ID: mdl-31763999

Assuntos

Estenose Coronária/metabolismo; Fibronectinas/metabolismo; Miócitos de Músculo Liso/metabolismo; Neointima/metabolismo; Transdução de Sinais; Animais; Estenose Coronária/genética; Estenose Coronária/patologia; Fibronectinas/genética; Quinase 1 de Adesão Focal/genética; Quinase 1 de Adesão Focal/metabolismo; Humanos; Hiperplasia; Camundongos; Camundongos Knockout para ApoE; Miócitos de Músculo Liso/patologia; Neointima/genética; Neointima/patologia; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Extracellular matrix; Fibronectin; Vascular Biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fibronectinas / Estenose Coronária / Miócitos de Músculo Liso / Neointima Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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