Rifabutin Is Active against Mycobacterium abscessus in Mice.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Article
em En
| MEDLINE
| ID: mdl-31767722
ABSTRACT
There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.
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Base de dados:
MEDLINE
Assunto principal:
Rifabutina
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Mycobacterium abscessus
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Pneumopatias
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Antibacterianos
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Infecções por Mycobacterium não Tuberculosas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article