The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Nat Commun
; 10(1): 5351, 2019 11 25.
Article
em En
| MEDLINE
| ID: mdl-31767858
ABSTRACT
Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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RNA Ribossômico
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Proteínas Nucleares
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Leucemia Mieloide
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RNA Longo não Codificante
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Mutação
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article