The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.

Kang, A Min; Padilla-Jones, Angela; Fisher, Erik S; Akakpo, Jephte Y; Jaeschke, Hartmut; Rumack, Barry H; Gerkin, Richard D; Curry, Steven C

Kang, A Min; Padilla-Jones, Angela; Fisher, Erik S; Akakpo, Jephte Y; Jaeschke, Hartmut; Rumack, Barry H; Gerkin, Richard D; Curry, Steven C.

Afiliação

Kang AM; Division of Clinical Data Analytics and Decision Support, and Division of Medical Toxicology and Precision Medicine, Department of Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA. aaron.kang@bannerhealth.com.
Padilla-Jones A; Department of Medical Toxicology, Banner - University Medical Center Phoenix, 1012 E. Willetta St., Fl 2, Phoenix, AZ, 85006, USA. aaron.kang@bannerhealth.com.
Fisher ES; Department of Medical Toxicology, Banner - University Medical Center Phoenix, 1012 E. Willetta St., Fl 2, Phoenix, AZ, 85006, USA.
Akakpo JY; Department of Medical Toxicology, Banner - University Medical Center Phoenix, 1012 E. Willetta St., Fl 2, Phoenix, AZ, 85006, USA.
Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Rumack BH; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Gerkin RD; Department of Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Curry SC; Department of Medical Toxicology, Banner - University Medical Center Phoenix, 1012 E. Willetta St., Fl 2, Phoenix, AZ, 85006, USA.

J Med Toxicol ; 16(2): 169-176, 2020 04.

Article em En | MEDLINE | ID: mdl-31768936

Assuntos

Acetaminofen/farmacocinética; Analgésicos não Narcóticos/farmacocinética; Inibidores do Citocromo P-450 CYP2E1/administração & dosagem; Citocromo P-450 CYP2E1/metabolismo; Fomepizol/administração & dosagem; Acetaminofen/administração & dosagem; Ativação Metabólica; Administração Oral; Adulto; Analgésicos não Narcóticos/administração & dosagem; Estudos Cross-Over; Interações Medicamentosas; Feminino; Humanos; Infusões Intravenosas; Masculino; Pessoa de Meia-Idade; Oxirredução

Palavras-chave

4-Methylpyrazole; Acetaminophen toxicity; CYP2E1; Hepatotoxicity; Overdose

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Analgésicos não Narcóticos / Citocromo P-450 CYP2E1 / Inibidores do Citocromo P-450 CYP2E1 / Fomepizol / Acetaminofen Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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