XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction.

García-Manzanares, María; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Martínez-Dolz, Luis; González-Juanatey, José Ramón; Lago, Francisca; Portolés, Manuel; Roselló-Lletí, Esther; Rivera, Miguel

García-Manzanares, María; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Martínez-Dolz, Luis; González-Juanatey, José Ramón; Lago, Francisca; Portolés, Manuel; Roselló-Lletí, Esther; Rivera, Miguel.

Afiliação

García-Manzanares M; Department of Animal Medicine and Surgery, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Tarazón E; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Ortega A; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Gil-Cayuela C; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Martínez-Dolz L; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
González-Juanatey JR; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Lago F; Heart Failure and Transplantation Unit, Cardiology Department, University Hospital La Fe, Valencia, Spain.
Portolés M; Cellular and Molecular Cardiology Research Unit, Department of Cardiology and Institute of Biomedical Research, University Clinical Hospital, Santiago de Compostela, Spain.
Roselló-Lletí E; Cellular and Molecular Cardiology Research Unit, Department of Cardiology and Institute of Biomedical Research, University Clinical Hospital, Santiago de Compostela, Spain.
Rivera M; Myocardial Dysfunction and Cardiac Transplantation Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. Fernando Abril Martorell, 106, 46026, Valencia, Spain. portoles_man@gva.es.

J Cardiovasc Transl Res ; 13(4): 593-600, 2020 08.

Article em En | MEDLINE | ID: mdl-31768947

Assuntos

Carioferinas/metabolismo; Contração Miocárdica; Infarto do Miocárdio/terapia; Miocárdio/metabolismo; RNA Interferente Pequeno/administração & dosagem; Terapêutica com RNAi; Receptores Citoplasmáticos e Nucleares/metabolismo; Função Ventricular Esquerda; Remodelação Ventricular; Animais; Modelos Animais de Doenças; Colágenos Fibrilares/metabolismo; Fibrose; Carioferinas/genética; Masculino; Infarto do Miocárdio/genética; Infarto do Miocárdio/metabolismo; Infarto do Miocárdio/fisiopatologia; Miocárdio/patologia; Interferência de RNA; Ratos Sprague-Dawley; Receptores Citoplasmáticos e Nucleares/genética; Proteína Exportina 1

Palavras-chave

Gene silencing; Myocardial infarction; Ventricular function; XPO1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Receptores Citoplasmáticos e Nucleares / Remodelação Ventricular / Carioferinas / RNA Interferente Pequeno / Terapêutica com RNAi / Contração Miocárdica / Infarto do Miocárdio / Miocárdio Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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