A criterion-based approach to systematic and transparent comparative effectiveness: a case study in psoriatic arthritis.
J Comp Eff Res
; 8(15): 1265-1298, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31774340
ABSTRACT
Aim:
Indirect treatment comparisons are used when no direct comparison is available. Comparison networks should satisfy the transitivity assumption, that is, equal likelihood of treatment assignment for a given patient based on comparability of studies. Materials &methods:
Seven criteria were evaluated across 18 randomized controlled trials in psoriatic arthritis inclusion/exclusion criteria, clinical trial design and follow-up, patient-level baseline characteristics, disease severity, prior therapies, concomitant and extended-trial treatment and placebo response differences.Results:
Across studies, placebo was a common comparator, and key efficacy end points were reported. Collectively, several potential sources of insufficient transitivity were identified, most often related to trial design and population differences.Conclusion:
Potential challenges in satisfying transitivity occur frequently and should be evaluated thoroughly.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Artrite Psoriásica
/
Ensaios Clínicos Controlados Aleatórios como Assunto
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article