Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells.

Wang, Shaojun; Zhang, Xiaofei; Wang, Guimei; Cao, Bin; Yang, Hong; Jin, Lipeng; Cui, Mingjuan; Mao, Yongjun

Wang, Shaojun; Zhang, Xiaofei; Wang, Guimei; Cao, Bin; Yang, Hong; Jin, Lipeng; Cui, Mingjuan; Mao, Yongjun.

Afiliação

Wang S; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Zhang X; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Wang G; Department of Geriatrics, The Affiliated Hospital of Qingdao University, No.59 Haier Road, Laoshan District, Qingdao, 266000, Shandong, China.
Cao B; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Yang H; Emergency Department, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Jin L; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Cui M; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Mao Y; Department of Geriatrics, The Affiliated Hospital of Qingdao University, No.59 Haier Road, Laoshan District, Qingdao, 266000, Shandong, China. yongjun23m@163.com.

BMC Cancer ; 19(1): 1160, 2019 Nov 29.

Article em En | MEDLINE | ID: mdl-31783811

Assuntos

Neoplasias Colorretais/patologia; Janus Quinase 1/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Sindecana-1/metabolismo; Quinases raf/metabolismo; Apoptose; Adesão Celular; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Expressão Gênica; Humanos; Sistema de Sinalização das MAP Quinases; Fosforilação; Sindecana-1/genética; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

Colorectal carcinoma; JAK1/STAT3; Migration; Ras/Raf/MEK/ERK; Syndecan-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Transdução de Sinais / Proteínas Proto-Oncogênicas p21(ras) / Quinases raf / Fator de Transcrição STAT3 / Janus Quinase 1 / Sindecana-1 Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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