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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
Cancer, Matko; Hutter, Sonja; Holmberg, Karl O; Rosén, Gabriela; Sundström, Anders; Tailor, Jignesh; Bergström, Tobias; Garancher, Alexandra; Essand, Magnus; Wechsler-Reya, Robert J; Falk, Anna; Weishaupt, Holger; Swartling, Fredrik J.
Afiliação
  • Cancer M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Hutter S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Holmberg KO; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Rosén G; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Sundström A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Tailor J; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
  • Bergström T; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Garancher A; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 92037 La Jolla, CA, USA.
  • Essand M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 92037 La Jolla, CA, USA.
  • Falk A; Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Weishaupt H; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Swartling FJ; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden. Electronic address: fredrik.swartling@igp.uu.se.
Cell Stem Cell ; 25(6): 855-870.e11, 2019 Dec 05.
Article em En | MEDLINE | ID: mdl-31786016
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Fator 3 de Transcrição de Octâmero / Serina-Treonina Quinases TOR / Meduloblastoma Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Fator 3 de Transcrição de Octâmero / Serina-Treonina Quinases TOR / Meduloblastoma Idioma: En Ano de publicação: 2019 Tipo de documento: Article