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Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.
Valero, Teresa; Baillache, Daniel J; Fraser, Craig; Myers, Samuel H; Unciti-Broceta, Asier.
Afiliação
  • Valero T; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Baillache DJ; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Fraser C; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Myers SH; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Unciti-Broceta A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address: Asier.Unciti-Broceta@igmm.ed.ac.uk.
Bioorg Med Chem ; 28(1): 115215, 2020 01 01.
Article em En | MEDLINE | ID: mdl-31787462
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Fosfatidilinositol 3-Quinases / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Fosfatidilinositol 3-Quinases / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR Idioma: En Ano de publicação: 2020 Tipo de documento: Article