Cortical hypoperfusion in patients with idiopathic rapid eye movement sleep behavior disorder detected with arterial spin-labeled perfusion MRI.
Neurol Sci
; 41(4): 809-815, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31792718
ABSTRACT
BACKGROUND:
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is an important risk factor for α-synucleinopathy.OBJECTIVE:
We investigated alterations in the cerebral blood flow (CBF) based on arterial spin-labeled (ASL) imaging in patients with iRBD to determine brain perfusion changes associated with the disorder.METHODS:
Fifteen patients with iRBD and twenty age-gender-matched healthy controls were enrolled. Cortical perfusions were compared between the two groups after the ASL data was co-registered to the high-resolution T1-weighted images.RESULTS:
No significant differences were detected between the groups in regard to age, gender, education, or UPDRS-III score. The iRBD group showed a lower MMSE score than the healthy controls (27.07 ± 2.25 vs. 28.55 ± 1.23, p < 0.05). Compared with the healthy controls, the iRBD group showed significantly decreased CBF values in the right inferior frontal gyrus, right middle frontal gyrus, and right insula (p < 0.05 corrected).CONCLUSION:
The cortical hypoperfusion areas in patients with iRBD were similar to the patterns in patients with α -synucleinopathies. ASL perfusion MRI is a potential approach to find biomarkers in preclinical stages of α -synucleinopathies.Palavras-chave
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MEDLINE
Assunto principal:
Córtex Cerebral
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Circulação Cerebrovascular
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Angiografia por Ressonância Magnética
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Transtorno do Comportamento do Sono REM
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Sinucleinopatias
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article