[Comparative studies of neurotrophic drugs based on brain hydrolysates]. / O sravnitel'nykh éksperimental'nykh issledovaniiakh neirotroficheskikh preparatov na osnove gidrolizatov golovnogo mozga.
Zh Nevrol Psikhiatr Im S S Korsakova
; 119(10): 134-140, 2019.
Article
em Ru
| MEDLINE
| ID: mdl-31793555
ABSTRACT
The results of the analysis of comparative studies of neurotrophic drugs based on brain hydrolysates (BH) are presented. The most comprehensive comparative study of the BH drugs carried out by Zhang, et al. 2019 investigated the effects of four drugs (cognistar, cerebrolysate, cortexin, cerebrolysin) on a model of ischemic stroke in rats. The study showed that a significant improvement in the neurological outcome compared with placebo was observed only with cerebrolysin. Higher standardization in elemental composition, higher antioxidant activity, and presence of active peptide fragments of neuropeptides of nerve growth factor, enkephalins, orexin and galanin in cerebrolysin explains neurotrophic and neuroprotective effects of the drug.
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Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
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Fármacos Neuroprotetores
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Acidente Vascular Cerebral
Idioma:
Ru
Ano de publicação:
2019
Tipo de documento:
Article