Structural characteristics of Medicago Sativa L. Polysaccharides and Se-modified polysaccharides as well as their antioxidant and neuroprotective activities.
Int J Biol Macromol
; 147: 1099-1106, 2020 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-31794828
ABSTRACT
Medicago Sativa L., a nutrient-rich plant used as feed for cattle and sheep, is widely planted globally. This study investigated the structural characteristics and activities of three kinds of novel polysaccharides (APS1, APS2 and APS3) isolated from the stems of M. sativa as well as its two selenium modified products (Se-APS2 and Se-APS3). APS1 (Mw = 13.4 KDa) and APS2 (Mw = 11.2 KDa) were composed of rhamnose, arabinose, mannose and galactose with different molar ratio, APS3 (Mw = 18.6 KDa) was composed of rhamnose, arabinose, fructose, mannose and galactose. All APS1-3 contained 1 â 3 1 â 6 1 â 4 1 â 2 glycosidic bonds in a ratio of 0.740.090.050.12, 0.340.200.360.10 and 0.630.170.060.14, respectively. The selenium content of Se-APS2 (Mw = 9.0 KDa) and Se-APS3 (Mw = 10.2 KDa) were 1.05 and 2.57 µg/mg, respectively. Their surface morphology and thermal stability were determined by scanning electron microscope (SEM) and thermal analysis (TGA), respectively. Further, the antioxidant and neuroprotective activities of the three natural polysaccharides and two Se-polysaccharides were studied. Interestingly, Se-polysaccharides not only exhibited higher antioxidant activity, but also higher neuroprotective activity compared to natural polysaccharides.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Selênio
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Sequestradores de Radicais Livres
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Medicago sativa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article