Anti-tumor activities and mechanism study of α-pinene derivative in vivo and in vitro.
Cancer Chemother Pharmacol
; 85(2): 367-377, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31797046
ABSTRACT
In previous study, we designed novel α-pinene derivatives based on theories of bioalkylating agents using α-pinene as lead compound and patented these compounds, in which compound α-pinene derivative GY-1 (6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl-4-methylbenzenesulfonat) showed strongest inhibition on hepatoma carcinoma cell BEL-7402. In this study, we investigated effect of GY-1 on hepatocellular carcinoma in vitro and in vivo, and explored its mechanism of anti-hepatoma. The results showed that GY-1 showed good anti-liver cancer activity with the IC50 of 84.7 µmol/L in vitro, inhibited tumor growth in vivo with dose-dependent, and GY-1 could arrest the growth of hepatoma cells in the S phase and induced apoptosis in hepatoma cells, down-regulated the expression of C-myc, CDK2 and CyclinE, and up-regulate p53.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monoterpenos Bicíclicos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article