Prognosis Factors in Chronic Lymphocytic Leukemia.
J Med Life
; 5(Spec Issue): 48-53, 2012.
Article
em En
| MEDLINE
| ID: mdl-31803286
ABSTRACT
Chronic lymphocytic leukemia is still one of the most common hematologic malignancies. Finding a curative solution is the objective of numerous followed cases and clinical trials. Diagnosis is based on the interlocking of classic elements and newly identified prognostic factors but time to first treatment is still an open issue. CD38, ZAP 70, IgHV gene mutational status and cytogenetic changes are proven negatively influence the evolution of chronic lymphocytic leukemia. Whether through aggressive rapid evolution or by the difficulty of obtaining a complete remission or risk of early relapse, CLL is still important. Adapted to these prognostic factors, combined therapeutic regimens have proved to be effective in achieving a durable complete remission, new agents, with encouraging partial results, being studied. Requiring initial screening, for comparative purposes, a current and growing importance has minimal residual disease; its absence at the end of treatment represents a strong positive prognostic factor.
CD38; CD38 - cluster of differentiation 38; CLL - Chronic lymphocytic leukemia; Chronic lymphocytic leukemia; IGHV - immunoglobulin heavy chain variable region genes; IgHV; LDT - lymphocyte doubling time; NK - natural killer cells; ZAP-70 the protein associated to zeta chain with the molecular weight of 70Kda; ZAP70; prognosis factors
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MEDLINE
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En
Ano de publicação:
2012
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Article