Pro-inflammatory cytokines are associated with podocyte damage and proximal tubular dysfunction in the early stage of diabetic kidney disease in type 2 diabetes mellitus patients.
J Diabetes Complications
; 34(2): 107479, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31806428
ABSTRACT
AIMS:
To evaluate if there is a link between inflammation (expressed by inflammatory cytokines) and the early stage of diabetic kidney disease (DKD), as shown by markers of podocyte damage and proximal tubular (PT) dysfunction.METHODS:
In this study were enrolled 117 type 2 DM patients (36-normoalbuminuria, 42-microalbuminuria, 39- macroalbuminuria), and 11 healthy subjects. Serum and urinary IL-1 alpha, IL-8, IL-18, urinary albumincreatinine ratio (UACR), eGFR, biomarkers of podocyte damage (podocalyxin, synaptopodin, nephrin) and of PT dysfunction (KIM-1, NAG) were assessed.RESULTS:
In multivariable regression urinary Il-1 alpha correlated positively with podocalyxin and NAG (pâ¯<â¯0.0001, R2=â¯0.57); urinary IL-8 correlated directly with synaptopodin, NAG, nephrin, and KIM-1 (pâ¯<â¯0.0001, R2â¯=â¯0.67); urinary IL-18 correlated directly with synaptopodin, NAG, and nephrin (pâ¯<â¯0.0001, R2â¯=â¯0.59). Serum IL-1 alpha correlated positively with nephrin, synaptopodin, NAG (Pâ¯<â¯0.0001, R2â¯=â¯0.68); serum IL-8 correlated directly with synaptopodin and NAG (pâ¯<â¯0.0001, R2â¯=â¯0.66); serum IL-18 correlated directly with NAG, KIM-1, and podocalyxin (pâ¯<â¯0.0001, R2=0.647).CONCLUSIONS:
Pro-inflammatory interleukins are associated with podocyte injury and PT dysfunction in early DKD. These could exert a key role in the pathogenesis of early DKD, before the development of albuminuria.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
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Diabetes Mellitus Tipo 2
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Nefropatias Diabéticas
/
Podócitos
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Túbulos Renais Proximais
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article