Nonsynonymous SNPs in <i>LPA</i> homologous to plasminogen deficiency mutants represent novel null apo(a) alleles.

Morgan, Benjamin M; Brown, Aimee N; Deo, Nikita; Harrop, Tom W R; Taiaroa, George; Mace, Peter D; Wilbanks, Sigurd M; Merriman, Tony R; Williams, Michael J A; McCormick, Sally P A

Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles.

Morgan, Benjamin M; Brown, Aimee N; Deo, Nikita; Harrop, Tom W R; Taiaroa, George; Mace, Peter D; Wilbanks, Sigurd M; Merriman, Tony R; Williams, Michael J A; McCormick, Sally P A.

Afiliação

Morgan BM; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand.
Brown AN; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand.
Deo N; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
Harrop TWR; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand.
Taiaroa G; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand.
Mace PD; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
Wilbanks SM; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand.
Merriman TR; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
Williams MJA; Department of Medicine, Dunedin School of Medicine,University of Otago, Dunedin, New Zealand.
McCormick SPA; Department of Biochemistry, School of Biomedical SciencesUniversity of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.

J Lipid Res ; 61(3): 432-444, 2020 03.

Article em En | MEDLINE | ID: mdl-31806727

Assuntos

Apoproteína(a)/genética; Lipoproteína(a)/genética; Plasminogênio/genética; Polimorfismo de Nucleotídeo Único/genética; Adulto; Idoso; Alelos; Linhagem Celular Tumoral; Estudos de Coortes; Humanos; Lipoproteína(a)/sangue; Masculino; Pessoa de Meia-Idade; Mutação; Plasminogênio/deficiência

Palavras-chave

Golgi; apolipoprotein (a); endoplasmic reticulum; kringle structure; null allele; protein modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasminogênio / Lipoproteína(a) / Polimorfismo de Nucleotídeo Único / Apoproteína(a) Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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