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Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes.
Zhang, Dandan; Meng, Ya-Ru; Zhang, Chun-Yang.
Afiliação
  • Zhang D; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China. cyzhang@sdnu.edu.cn.
Chem Commun (Camb) ; 56(2): 213-216, 2019 Dec 19.
Article em En | MEDLINE | ID: mdl-31808495
We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous detection of multiple posttranslational modification (PTM) enzymes with a detection limit of 28 pM for histone deacetylase (HDAC) and 0.8 pM for protein tyrosine phosphatase 1B (PTP1B), and it can be further applied for the screening of PTM enzyme inhibitors and the measurement of PTM enzymes in cancer cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfopeptídeos / Nanopartículas Metálicas / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Histona Desacetilases Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfopeptídeos / Nanopartículas Metálicas / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Histona Desacetilases Idioma: En Ano de publicação: 2019 Tipo de documento: Article