NicheNet: modeling intercellular communication by linking ligands to target genes.
Nat Methods
; 17(2): 159-162, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31819264
ABSTRACT
Computational methods that model how gene expression of a cell is influenced by interacting cells are lacking. We present NicheNet (https//github.com/saeyslab/nichenetr), a method that predicts ligand-target links between interacting cells by combining their expression data with prior knowledge on signaling and gene regulatory networks. We applied NicheNet to tumor and immune cell microenvironment data and demonstrate that NicheNet can infer active ligands and their gene regulatory effects on interacting cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Modelos Teóricos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article