[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies]. / Prenilációgátlás hatása RAS-mutáns daganatokra kísérleti rendszerekben.
Magy Onkol
; 63(4): 320-329, 2019 Dec 09.
Article
em Hu
| MEDLINE
| ID: mdl-31821387
ABSTRACT
Oncogenic mutation of RAS occurs in 20-25% of all malignancies. Our research group have examined inhibition of RAS prenylation on RAS wild type and RAS mutated melanoma, colorectal cancer and lung adenocarcinoma cell lines. Effects of clinically approved bisphosphonate (zoledronic acid) and its lipophilic derivate (BPH1222) on cell viability and cell signaling were determined. In models of melanoma and colorectal cancer we found no relevant difference in sensitivity to the drugs in light of RAS mutation presence. In case of lung adenocarcinoma bisphosphonate treatment inhibited both wild-type and mutated K-RAS, although tumor cells carrying mutated K-RAS seemed to be more sensitive to the bisphosphonate treatment. In summary, further investigations are warranted to identify tumor subgroups where bisphosphonates could have an effective therapeutic potential.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas ras
/
Mutação
/
Neoplasias
Idioma:
Hu
Ano de publicação:
2019
Tipo de documento:
Article