Synthesis of Carboxy ATTO 647N Using Redox Cycling for Xanthone Access.
Org Lett
; 22(2): 381-385, 2020 01 17.
Article
em En
| MEDLINE
| ID: mdl-31825225
ABSTRACT
A synthesis of the carbopyronine dye Carboxy ATTO 647N from simple materials is reported. This route proceeds in 11 forward steps from 3-bromoaniline with the key xanthone intermediate formed using a new oxidation methodology. The step utilizes an oxidation cycle with base, water, iodine, and more than doubles the yield of the standard permanganate oxidation methodology, accessing gram-scale quantities of this late-stage product. From this, Carboxy ATTO 647N was prepared in only four additional steps. This facile route to a complex fluorophore is expected to enable further studies in fluorescence imaging.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pironina
/
Xantonas
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article