Genome mining integrating semi-rational protein engineering and nanoreactor design: roadmap for a robust biocatalyst for industrial resolution of Vince lactam.

Li, Hongxia; Gao, Shuaihua; Qiu, Yan; Liang, Chaoqun; Zhu, Shaozhou; Zheng, Guojun

Li, Hongxia; Gao, Shuaihua; Qiu, Yan; Liang, Chaoqun; Zhu, Shaozhou; Zheng, Guojun.

Afiliação

Li H; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Gao S; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Qiu Y; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Liang C; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Zhu S; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Zheng G; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.

Appl Microbiol Biotechnol ; 104(3): 1109-1123, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31828408

Assuntos

Actinobacteria/genética; Amidoidrolases/metabolismo; Genoma; Lactamas/metabolismo; Engenharia de Proteínas/métodos; Actinobacteria/enzimologia; Biocatálise; Microbacterium; Estereoisomerismo

Palavras-chave

Biocatalysis; Carbocyclic nucleoside; Direct evolution; Protein nanoreactor; Self-assembling; Semi-rational engineering; Vince lactam

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Genoma / Actinobacteria / Amidoidrolases / Lactamas Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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