Crellastatin A, a PARP-1 Inhibitor Discovered by Complementary Proteomic Approaches.

Morretta, Elva; Tosco, Alessandra; Festa, Carmen; Mozzicafreddo, Matteo; Monti, Maria C; Casapullo, Agostino

Morretta, Elva; Tosco, Alessandra; Festa, Carmen; Mozzicafreddo, Matteo; Monti, Maria C; Casapullo, Agostino.

Afiliação

Morretta E; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano Salerno, Italy.
Tosco A; Department of Pharmacy PhD Program in Drug Discovery and Development, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano Salerno, Italy.
Festa C; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano Salerno, Italy.
Mozzicafreddo M; Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131, Napoli, Italy.
Monti MC; School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032, Camerino, Italy.
Casapullo A; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano Salerno, Italy.

ChemMedChem ; 15(3): 317-323, 2020 02 05.

Article em En | MEDLINE | ID: mdl-31829516

Assuntos

Noresteroides/farmacologia; Poli(ADP-Ribose) Polimerase-1/antagonistas & inibidores; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Proteômica; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Noresteroides/química; Poli(ADP-Ribose) Polimerase-1/metabolismo; Inibidores de Poli(ADP-Ribose) Polimerases/química; Relação Estrutura-Atividade

Palavras-chave

functional proteomics; mass spectrometry.; molecular docking; natural products; target discovery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteômica / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Noresteroides Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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