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Construction of a circularly connected VHH bispecific antibody (cyclobody) for the desirable positioning of antigen-binding sites.
Hemmi, Saki; Asano, Ryutaro; Kimura, Kouki; Umetsu, Mitsuo; Nakanishi, Takeshi; Kumagai, Izumi; Makabe, Koki.
Afiliação
  • Hemmi S; Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jyonan, Yonezawa, Yamagata, 992-8510, Japan.
  • Asano R; Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 183-8538, Japan.
  • Kimura K; Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 183-8538, Japan.
  • Umetsu M; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 6-6-11-606 Aoba-yama, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8579, Japan.
  • Nakanishi T; Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka, 558-8585, Japan.
  • Kumagai I; Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 183-8538, Japan.
  • Makabe K; Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jyonan, Yonezawa, Yamagata, 992-8510, Japan. Electronic address: makabe@yz.yamagata-u.ac.jp.
Biochem Biophys Res Commun ; 523(1): 72-77, 2020 02 26.
Article em En | MEDLINE | ID: mdl-31831177
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Ligação de Anticorpos / Receptores de Antígenos / Anticorpos Biespecíficos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Ligação de Anticorpos / Receptores de Antígenos / Anticorpos Biespecíficos Idioma: En Ano de publicação: 2020 Tipo de documento: Article