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FABP5 coordinates lipid signaling that promotes prostate cancer metastasis.
Carbonetti, Gregory; Wilpshaar, Tessa; Kroonen, Jessie; Studholme, Keith; Converso, Cynthia; d'Oelsnitz, Simon; Kaczocha, Martin.
Afiliação
  • Carbonetti G; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Wilpshaar T; Department of Anesthesiology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Kroonen J; Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Studholme K; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Converso C; Department of Anesthesiology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • d'Oelsnitz S; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Kaczocha M; Department of Anesthesiology, Stony Brook University, Stony Brook, NY, 11794, USA.
Sci Rep ; 9(1): 18944, 2019 12 12.
Article em En | MEDLINE | ID: mdl-31831821
ABSTRACT
Prostate cancer (PCa) is defined by dysregulated lipid signaling and is characterized by upregulation of lipid metabolism-related genes including fatty acid binding protein 5 (FABP5), fatty acid synthase (FASN), and monoacylglycerol lipase (MAGL). FASN and MAGL are enzymes that generate cellular fatty acid pools while FABP5 is an intracellular chaperone that delivers fatty acids to nuclear receptors to enhance PCa metastasis. Since FABP5, FASN, and MAGL have been independently implicated in PCa progression, we hypothesized that FABP5 represents a central mechanism linking cytosolic lipid metabolism to pro-metastatic nuclear receptor signaling. Here, we show that the abilities of FASN and MAGL to promote nuclear receptor activation and PCa metastasis are critically dependent upon co-expression of FABP5 in vitro and in vivo. Our findings position FABP5 as a key driver of lipid-mediated metastasis and suggest that disruption of lipid signaling via FABP5 inhibition may constitute a new avenue to treat metastatic PCa.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Transdução de Sinais / Proteínas de Ligação a Ácido Graxo / Metabolismo dos Lipídeos / Ácidos Graxos / Proteínas de Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Transdução de Sinais / Proteínas de Ligação a Ácido Graxo / Metabolismo dos Lipídeos / Ácidos Graxos / Proteínas de Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article