TAAR Agonists.
Cell Mol Neurobiol
; 40(2): 257-272, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31848873
ABSTRACT
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors (GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is mainly expressed in the brain, and is able to detect low abundant trace amines. TAAR1 is also activated by several synthetic compounds and psychostimulant drugs like amphetamine. Activation of TAAR1 by specific agonists can regulate the classical monoaminergic systems in the brain. Further studies have revealed that other TAAR family members are highly expressed in the olfactory system which are termed olfactory TAARs. In vertebrates, olfactory TAARs can specifically recognize volatile or water-soluble amines. Some of these TAAR agonists are produced by decarboxylation of amino acids. In addition, some TAAR agonists are ethological odors that mediate animal innate behaviors. In this study, we provide a comprehensive review of TAAR agonists, including their structures, biosynthesis pathways, and functions.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aminas Biogênicas
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Receptores Acoplados a Proteínas G
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Estimulantes do Sistema Nervoso Central
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article