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Knockdown of SLC35F2 Inhibits the Proliferation and Metastasis of Bladder Cancer Cells.
Chen, Mei; Gao, Xin; Huang, Denggao; Wang, Shunlan; Zheng, Linlin; Chen, Yinyi; Wen, Xiaohong; Gao, Yuanhui; Cao, Hui; Zhang, Shufang.
Afiliação
  • Chen M; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Gao X; Clinical Laboratory, The First People's Hospital of Huaihua, Huaihua 418000, People's Republic of China.
  • Huang D; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Wang S; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Zheng L; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Chen Y; Clinical Laboratory, The First Affiliated Hospital of University of South China, Hengyang 421001, People's Republic of China.
  • Wen X; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Gao Y; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Cao H; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
  • Zhang S; Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, People's Republic of China.
Onco Targets Ther ; 12: 10771-10786, 2019.
Article em En | MEDLINE | ID: mdl-31849485
BACKGROUND: Many studies have shown that solute carrier family 35 member F2 (SLC35F2) plays a key role in the biological processes of multiple cancers. However, there have been no reports on the role of SLC35F2 in the occurrence and development of bladder cancer (BC). METHODS: SLC35F2 expression data and clinical and prognostic information from BC patients were obtained from databases. SLC35F2 expression in BC was verified by quantitative real-time PCR (qRT-PCR). The influence of SLC35F2 knockdown on the proliferation, apoptosis, migration and invasion in the 5637 and T24 cell lines was studied, and tumor formation experiments were performed in nude mice. Gene set enrichment analysis (GSEA) was used to predict the pathways and functions of SLC35F2 in BC. RESULTS: SLC35F2 was highly expressed in BC tissues and was associated with invasiveness and T stage in BC patients. SLC35F2 knockdown can inhibit the proliferation, migration and invasion of BC cells and can promote apoptosis. SLC35F2 knockdown significantly reduced tumorigenesis in nude mice. GSEA showed that BC, pathways in cancer, apoptosis and the P53 signaling pathway were significantly enriched in SLC35F2 high expression phenotype. CONCLUSION: SLC35F2 can promote malignant progression and is a potential therapeutic target in BC.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article