[Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia].
Zhonghua Xue Ye Xue Za Zhi
; 40(11): 939-942, 2019 Nov 14.
Article
em Zh
| MEDLINE
| ID: mdl-31856444
ABSTRACT
Objective:
To analyze the correlation between plasma trough level of generic imatinib and its metabolism and clinical outcomes in Chinese patients with chronic myeloid leukemia in chronic phase (CML-CP) .Methods:
The 21 patients with CML-CP who enrolled in a clinical trial YMTN 1.0 from Oct 11(th), 2012 to May 8(th), 2013 and received generic imatinib were as study subjects. The correlation between steady plasma trough levels of imatinib and its metabolism with clinical response, age, weight and body surface area (BSA) were evaluated.Results:
â The mean steady plasma trough level of generic imatinib and its metabolism was (1 185.07±417.91) µg/L and (251.53±76.50) µg/L, respectively. â¡Age, weight and BSA has no significant effects on plasma trough level of generic imatinib and its metabolism (P>0.05) . â¢Patients with steady plasma trough level of generic imatinib more than 1 000 µg/L are possible to have higher major molecular response (MMR) /complete molecular response (CMR) rate than those below 1 000 µg/L (42% vs 0, P<0.05) .Conclusion:
Plasma trough levels of generic imatinib varied in CML patients. The steady plasma trough levels of generic imatinib is maybe related to molecular response in CML patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Mesilato de Imatinib
Idioma:
Zh
Ano de publicação:
2019
Tipo de documento:
Article