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Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization.
Karpov, Alexei S; Nieto-Oberhuber, Cristina M; Abrams, Tinya; Beng-Louka, Edwige; Blanco, Enrique; Chamoin, Sylvie; Chene, Patrick; Dacquignies, Isabelle; Daniel, Dylan; Dillon, Michael P; Doumampouom-Metoul, Lionel; Drosos, Nikolaos; Fedoseev, Pavel; Furegati, Markus; Granda, Brian; Grotzfeld, Robert M; Hess Clark, Suzanna; Joly, Emilie; Jones, Darryl; Lacaud-Baumlin, Marion; Lagasse-Guerro, Stephanie; Lorenzana, Edward G; Mallet, William; Martyniuk, Piotr; Marzinzik, Andreas L; Mesrouze, Yannick; Nocito, Sandro; Oei, Yoko; Perruccio, Francesca; Piizzi, Grazia; Richard, Etienne; Rudewicz, Patrick J; Schindler, Patrick; Velay, Mélanie; Venstrom, Kristine; Wang, Peiyin; Zurini, Mauro; Lafrance, Marc.
Afiliação
  • Karpov AS; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Nieto-Oberhuber CM; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Abrams T; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Beng-Louka E; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Blanco E; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Chamoin S; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Chene P; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Dacquignies I; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Daniel D; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Dillon MP; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Doumampouom-Metoul L; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Drosos N; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Fedoseev P; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Furegati M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Granda B; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Grotzfeld RM; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Hess Clark S; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Joly E; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Jones D; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Lacaud-Baumlin M; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Lagasse-Guerro S; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Lorenzana EG; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Mallet W; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Martyniuk P; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Marzinzik AL; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Mesrouze Y; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Nocito S; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Oei Y; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Perruccio F; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Piizzi G; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Richard E; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Rudewicz PJ; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Schindler P; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Velay M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Venstrom K; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Wang P; Novartis Institutes for BioMedical Research, Fabrikstrasse 2, CH-4056 Basel, Switzerland.
  • Zurini M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Lafrance M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
ACS Med Chem Lett ; 10(12): 1674-1679, 2019 Dec 12.
Article em En | MEDLINE | ID: mdl-31857845
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article