Synthesis of Phosphoramidite Monomers Equipped with Complementary Bases for Solid-Phase DNA Oligomerization.
Org Lett
; 22(1): 41-45, 2020 01 03.
Article
em En
| MEDLINE
| ID: mdl-31860314
ABSTRACT
We describe the preparation of two monomers that bear complementary nucleobases at the edges (guanine-2'-deoxycytidine and 2-aminoadenine-2'-deoxyuridine) and that are conveniently protected and activated for solid-phase automated DNA synthesis. We report the optimized synthetic routes leading to the four nucleobase derivatives involved, their cross-coupling reactions into dinucleobase-containing monomers, and their oligomerization in the DNA synthesizer.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
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DNA
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Técnicas de Síntese em Fase Sólida
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article