Syntaxin 16's Newly Deciphered Roles in Autophagy.
Cells
; 8(12)2019 12 17.
Article
em En
| MEDLINE
| ID: mdl-31861136
ABSTRACT
Syntaxin 16, a Qa-SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor), is involved in a number of membrane-trafficking activities, particularly transport processes at the trans-Golgi network (TGN). Recent works have now implicated syntaxin 16 in the autophagy process. In fact, syntaxin 16 appears to have dual roles, firstly in facilitating the transport of ATG9a-containing vesicles to growing autophagosomes, and secondly in autolysosome formation. The former involves a putative SNARE complex between syntaxin 16, VAMP7 and SNAP-47. The latter occurs via syntaxin 16's recruitment by Atg8/LC3/GABARAP family proteins to autophagosomes and endo-lysosomes, where syntaxin 16 may act in a manner that bears functional redundancy with the canonical autophagosome Qa-SNARE syntaxin 17. Here, I discuss these recent findings and speculate on the mechanistic aspects of syntaxin 16's newly found role in autophagy.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Sintaxina 16
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article